ETH News

Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men.

If the body’s natural stress response gets knocked off balance, it can result in physical and mental health disorders. Researchers at ETH Zurich have developed an agent capable of selectively inhibiting this response.

There are some striking parallels between how skin wounds heal and how malignant tumours grow. Cell culture can help us understand the mechanisms involved – but animal testing still has a role to play.

Researchers at ETH Zurich have now shown that a previously unknown protein plays a key role in a congenital malformation of the heart. Their findings point the way towards new treatment options.

Researchers at ETH Zurich have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.

"We will rock you": ETH Zurich researchers are developing a gene switch that triggers insulin release in designer cells by playing certain rock and pop songs.

A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases – and for those who would like to eat meat, but don’t want to kill animals.

Kantonsspital Baden (KSB) and ETH Zurich have been working together since 2017, mainly in teaching initially, but increasingly in clinical research. Now three ETH professors are moving into new premises on the hospital’s healthcare campus. Together, they want to make findings from basic research available for the benefit of patients.

A fuel cell under the skin that converts blood sugar from the body into electrical energy sounds like science fiction. Yet it works perfectly, as an ETH Zurich research team led by Martin Fussenegger, Professor of Biotechnology and Bioengineering, has shown.

Emotional trauma can have far-reaching ripple effects and may even reverberate across generations. Professors Isabelle Mansuy and Katharina Gapp study how the effects of trauma can be inherited through epigenetic mechanisms.

Up to now, the use of models to research the barrier that separates the circulatory from the nervous system has proven to be either limited or extremely complicated. Researchers at ETH Zurich have developed a more realistic model that can also be used to better explore new treatments for brain tumours.

Researchers at ETH Zurich are growing human brain-like tissue from stem cells and are then mapping the cell types that occur in different brain regions and the genes that regulate their development.

Researchers from ETH Zurich, University Hospital of Bern and the University of Bern have equipped gut bacteria with data logger functionality as a way of monitoring which genes are active in the bacteria. These microorganisms could one day offer a noninvasive means of diagnosing disease or assessing the impact of a diet on health.

Researchers have developed a new method that uses artificial intelligence to analyse animal behaviour. This opens the door to longer-term in-depth studies in the field of behavioural science – while also helping to improve animal welfare. The method is already being tested at Zurich Zoo.

In experiments on mice, researchers at ETH Zurich show that non-essential amino acids act as appetite suppressants and promote the urge to move. Their research provides insight into the neural mechanism that controls this behaviour.

Johannes Bohacek explains why it’s misleading to think we can completely replace animal testing with alternative methods, and why we should lower rather than raise the hurdles to research.

ETH Zurich and the other Swiss universities are committed to reducing the stress and suffering experienced by laboratory animals. However, an outright ban on animal testing – being put to the vote in a popular initiative this coming February – would put an end to progress in medical research.

It’s a good thing if animal testing is widely discussed in society, says Detlef Günther, but it’s important that these discussions are fair and fact-based.

These days, the cause of death in cancer patients often isn’t the primary tumour, but metastases. With his research, biochemist Nicola Aceto has found a new way to prevent the formation of such secondary tumours. To achieve this, the Latsis laureate had to repeatedly fight against the prevailing wisdom.

Green tea is seen as healthy and promotes a longer life supposedly due to its high level of antioxidants. Researchers at ETH Zurich have now cast doubt on previous assumptions about how these ingredients work.

Michael Kreuzer, Professor of Animal Nutrition and pioneer in the prevention of greenhouse gas emissions from livestock, is retiring after 27 years at ETH Zurich.

Roe deer are among the few mammals whose embryos go into a particularly long period of dormancy. Using modern molecular methods, ETH Zurich researchers have shown for the first time exactly what happens to the embryo during this phase. They have identified signals that control the embryo`s awakening.

ETH Zurich Professor Katrien De Bock and her team have discovered a certain type of blood vessel cell in muscles that multiplies rapidly upon exercise, thereby forming new blood vessels. Researchers can use this to find novel therapies for vascular disorders of the muscle.

Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.

Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-invasively.  

When researchers at ETH Zurich compared the reference genomes between several breeds of domestic cattle and closely related wild cattle, they discovered genes with previously unknown functions.

ETH Fellow Rodrigo Arzate-Mejia is studying how traumatic life experiences affect the brain, with a focus on epigenetic changes in brain cells.  

Without animal experiments there would be no COVID-19 vaccine: animal testing is essential for medical research. A ban on testing – even a gradual phase-out – would be extremely damaging for research policy, writes Detlef Günther.

Over the course of the EU project “FIThydro”, research and industry partners studied the ecological impact of hydropower plants. ETH Zurich’s Laboratory of Hydraulics, Hydrology and Glaciology (VAW) has developed a protection and guidance system that can help migratory fish to safely bypass hydropower turbines.

Researchers at ETH Zurich – in collaboration with colleagues from EPFL in Lausanne and Harvard Medical School – have developed a system that allows them to optically stimulate individual nerve fibres in living mice. Through this process, they have demonstrated that the nervous system has a direct influence on the immune system.

Despite the coronavirus lockdown, the renovation and extension of Früebüel research station in Walchwil (Canton of Zug) was completed nearly on schedule. AgroVet–Strickhof, a research cooperative supported by ETH Zurich, the University of Zurich and Strickhof, now has state-of-the-art research and higher education facilities at its four locations.

Vanesa Rocha Martin is studying how bacteria can be used to treat infant colic. As part of her Pioneer Fellowship, she is now turning her findings into a first-line therapy with a proven effect.

ETH researchers have deconstructed the mechanisms that control wound healing and scar formation in more detail. To this end, biologists and engineers have developed a new method that allows the biomechanical properties of the healing tissue to be measured in vivo for the first time.

The calcification of blood vessels and other soft tissues is problematic. Researchers at ETH Zurich and ETH spin-off Inositec have discovered a substance that prevents vascular calcification.

Zebra finches are very efficient at learning their courtship songs, as researchers from ETH Zurich and the University of Zurich have shown. In the morning, the birds remember the positive learning progress of the previous day, but forget the failures overnight.

Researchers from the University Hospital and ETH Zurich have developed a machine that repairs injured human livers and keep them alive outside the body for one week. This breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer.

Researchers from ETH Zurich and the National University of Singapore have developed a new kind of bandage that helps blood to clot and doesn’t stick to the wound. This marks the first time that scientists have combined both properties in one material.

A protective membrane for cardiac pacemakers developed at ETH Zurich has proved successful in animal trials in reducing the undesirable build-up of fibrotic tissue around the implant. The next step is to test the protective membrane in patients.