Vaccinating animals against Salmonella

Breeding animals often suffer from diarrhoea caused by Salmonella, but since the bacterium is constantly changing, previous vaccines quickly become ineffective. Wolf-​Dietrich Hardt, Emma Wetter Slack and Médéric Diard have developed a vaccine that exploits this genetic modification. Their vaccine triggers an immune response that directs the evolution of Salmonella in such a way that the only survivors are harmless pathogens that are also difficult to transmit to other animals.

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Video: ETH Zurich
the three researchers
From left to right: Wolf-Dietrich Hardt, Emma Wetter Slack, Médéric Diar Source: ETH Zurich, Martin Rütsche

Contact / Links:

Prof. Emma Slack, Laboratory for Food Immunology

Prof. Wolf-Dietrich Hardt, Institute of Microbiology

Publications:

patent pending (for further information contact )

“Tailored intestinal IgA responses can set an evolutionary trap for Salmonella Typhimurium”, Preprint available on request  

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